tag:blogger.com,1999:blog-6123453264169963762.post5290641455040100158..comments2023-04-27T18:37:40.633-07:00Comments on Pinata of Pathology: Prednisone Hydrocortisone Flip Flop Flim FlamMedical Mojavehttp://www.blogger.com/profile/14445140579589340514noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-6123453264169963762.post-81137993228969911202010-12-19T18:38:06.691-08:002010-12-19T18:38:06.691-08:00we're all different ..and each day is differen...we're all different ..and each day is different. i've been on hydrocortosone and gone into crisis, had it only help and not cause problems,and yet another time that it did diddly squat (neither good nor bad) . <br />I have 2 autoimmune diseases (and many many other issues)I have myasthenia gravis and lupus. <br />I take prednisone (80 mg per day) and will likely never be on any lower than 5 mg for the rest of my life. <br /><br />we all have to do what we've got to do ... <br /><br />I just found your blog, looks like we have some things in common (#'s 1,3,7,9,11 and nodule w/enlarged thyroid ..no dx, and PCOS... my moles have been mostly either fine, pre cancerous .. 2 melanoma and 1 non melanoma cancerous ...14 total removed add migrains, MG, SLE ... and a bit more)Dreaming againhttps://www.blogger.com/profile/15717590226520457326noreply@blogger.comtag:blogger.com,1999:blog-6123453264169963762.post-43834882869203905382010-12-19T04:56:52.585-08:002010-12-19T04:56:52.585-08:00As I know it, the theory was that hydrocortisone s...As I know it, the theory was that hydrocortisone suppressed the adrenal axis less than prednisone.<br /><br />So, the hydrocortisone was initially supplemented to whatever was actually needed. Cortisol is usually highest in the a.m., then drops off. So 3/4 of the hydrocortisone was given in the morning, then 1/4 around 2-3 in the afternoon. <br /><br />Is the afternoon when you are crashing?<br /><br />In my husband's case, after being on the hydrocortisone for a while (months) his adrenals were awake enough to attempt a taper (he went 2 days with no steroids, did a a.m. cortisol). He didn't feel well, but didn't fall over, and got an 9, so they decided to go ahead and try a taper. Then, the afternoon dose was the first dropped.<br /><br />It sounds to me like you are nowhere near being able to taper. I'd suspect the prednisone has your adrenals good and suppressed, and they may need some time on hydrocortisone to (hopefully) wake up. Sounds to me like you need twice a day dosing for a while too - since it seems that the hydrocortisone works, for the first half of the day. Personally, I'd prefer 2x dosing of hydrocortisone, rather than going back to pred (although I understand the weekend thingy).<br /><br />I'm no endo, but have seen how a really top endo does it, so that's what I'm going on.<br /><br />Hopefully, they figure out something that works for you soon.<br /><br />Tracy2Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-6123453264169963762.post-70218794677398953482010-12-18T05:51:59.915-08:002010-12-18T05:51:59.915-08:00Sounds like you gotta good doc this time. Hope the...Sounds like you gotta good doc this time. Hope the weekend goes/went well.Leahhttp://www.kaplooey.comnoreply@blogger.com